Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice
Pirfenidone shows potential as an anticonvulsant, anti-inflammatory, hepatoprotective, and neuroprotective agent, with additional benefits in improving cognition and oxidative stress profiles in epilepsy treatment. Further studies are required to explore its long-term safety and efficacy.
Authors
- Divya Vohora (ORCID: https://orcid.org/0000-0003-1852-9191)
- Mansi Dahalia
- Haya Majid (ORCID: https://orcid.org/0000-0003-1439-1172)
- Nidhi Agarwal (ORCID: https://orcid.org/0000-0002-2509-3026)
- Sparsh Gupta (ORCID: https://orcid.org/0000-0003-0019-2690)
Institutions
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
- Jamia Hamdard (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fphar.2024.1528032
- Citations
- 13
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 19.74