Evaluation of the inhibitory effect of different molecular weights chitosan on MRGPRX2-mediated mast cell degranulation and the pseudo-allergic reaction
Chitosan inhibited MRGPRX2-mediated MC degranulation <i>in vivo</i> and <i>in vitro</i>. Low molecular weight chitosan has the potential to be developed as a functional drug or food to assist in the treatment of MRGPRX2-regulated diseases.
Authors
- Ruiqi Li (ORCID: https://orcid.org/0009-0009-5513-1263)
- Dewu Zhang (ORCID: https://orcid.org/0000-0001-6289-0617)
- Yajing Hou
- Ruirui Lu (ORCID: https://orcid.org/0000-0001-6584-3277)
- Liping Liu (ORCID: https://orcid.org/0000-0002-6500-7217)
- Juan Li (ORCID: https://orcid.org/0000-0002-1979-9049)
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1080/08923973.2025.2457971
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00