BANNMDA: a computational model for predicting potential microbe–drug associations based on bilinear attention networks and nuclear norm minimization
The experimental results indicated that BANNMDA outperformed state-of-the-art competitive methods. We conducted case studies on well-known drugs such as the Amoxicillin and Ceftazidime, as well as on pathogens such as <i>Bacillus cereus</i> and Influenza A virus, to further evaluate the efficacy of BANNMDA, and experimental outcomes showed that there were 9 out of the top 10 predicted drugs, along with 8 and 9 out of the top 10 predicted microbes having been corroborated by relevant literatures. These findings underscored the capability of BANNMDA to achieve commendable predictive accuracy.
Authors
- Qijia Chen
- Bin Zeng (ORCID: https://orcid.org/0000-0002-1905-8929)
- Juncai Li (ORCID: https://orcid.org/0000-0002-3169-8646)
- Zhong Wang (ORCID: https://orcid.org/0000-0002-6206-526X)
- Lei Wang (ORCID: https://orcid.org/0000-0002-5065-8447)
- Xianzhi Liu (ORCID: https://orcid.org/0000-0002-6646-273X)
- Mingmin Liang
Institutions
- Changsha University (CN)
- Hunan Vocational College of Safety Technology (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fmicb.2024.1497886
- Citations
- 2
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province