Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines
The differences in anticancer effect might be linked to the changes and direct activity of bioavailable metabolites. The non-transformed AV extract affected neither normal nor cancer colon cells, indicating the beneficial effect of the biotransformation procedure on the anticancer properties of the evaluated extracts. The above results clearly indicate that microbial metabolism is a crucial factor that is potent in altering the biological activity of lady's mantle extract.
Authors
- Michał Tomczyk (ORCID: https://orcid.org/0000-0002-4063-1048)
- Jakub W. Strawa (ORCID: https://orcid.org/0000-0001-7133-1817)
- Katarzyna Jakimiuk (ORCID: https://orcid.org/0000-0001-7702-6493)
- Sebastian Granica (ORCID: https://orcid.org/0000-0002-1876-1321)
- Adrian Wiater (ORCID: https://orcid.org/0000-0003-1433-3634)
- Marta Kinga Lemieszek (ORCID: https://orcid.org/0000-0001-9367-0684)
- Aleksandra Kruk (ORCID: https://orcid.org/0000-0001-5323-7093)
Institutions
- Medical University of Białystok (PL)
- Maria Curie-Skłodowska University (PL)
- Medical University of Warsaw (PL)
- Instytut Medycyny Wsi im. Witolda Chodźki (PL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fphar.2025.1504787
- Citations
- 2
- Primary Topic
- Pomegranate: compositions and health benefits
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Narodowe Centrum Nauki