Effectiveness of antimicrobial agent combinations against carbapenem-producing Klebsiella pneumoniae with KPC variants in China
Our study suggests that the combinations of antimicrobial agent could serve as potential treatment strategies against CRKP infections. Furthermore, the effectiveness of these combinations is influenced by the types of carbapenemases present. Ceftazidime/avibactam-based combinations have showed superior synergistic effects on KPC variant-producing CRKP strains.
Authors
- Hongwei Zhou (ORCID: https://orcid.org/0000-0002-9478-4023)
- Danxia Gu (ORCID: https://orcid.org/0000-0002-9786-7780)
- Ning Dong (ORCID: https://orcid.org/0000-0003-1078-2192)
- Gongxiang Chen
- Zelin Yan (ORCID: https://orcid.org/0009-0008-8984-2031)
- Yanyan Zhang (ORCID: https://orcid.org/0000-0002-6053-2776)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-2174-7985)
- Congcong Liu (ORCID: https://orcid.org/0000-0002-1989-6711)
- Chang Cai (ORCID: https://orcid.org/0000-0002-1122-3045)
- Yuchen Wu (ORCID: https://orcid.org/0009-0001-9241-7422)
Institutions
- Zhejiang A & F University (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Soochow University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fmicb.2024.1519319
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China