Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation
This study defined a novel TCMR-associated cytokine gene set that effectively predicts TCMR and identified PPARγ agonists, which prevent TCMR and improve graft survival when combined with rapamycin.
Authors
- Weiqi Zhang (ORCID: https://orcid.org/0009-0002-5665-8189)
- Shuai Jin (ORCID: https://orcid.org/0000-0003-4314-1834)
- Jianming Zheng (ORCID: https://orcid.org/0000-0003-1471-9078)
- Jie Zhao (ORCID: https://orcid.org/0000-0002-6370-9549)
- Xiaolei Zhang (ORCID: https://orcid.org/0000-0001-9415-3136)
- Lu Hu
- Zhongyang Shen (ORCID: https://orcid.org/0000-0002-6545-2011)
- Wenli Song
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1539645
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China