Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS
Our epigenetics-based model demonstrates excellent prognostic accuracy (AUC>0.997 in internal validation, 0.832-0.929 in external cohorts) and provides a practical tool for treatment stratification. These findings establish a clinically applicable framework for personalized therapy selection in OS patients.
Authors
- Binshan Zhang
- K.-H. Chi (ORCID: https://orcid.org/0009-0008-0240-8794)
- Chaoyi Yin
- Yongsheng Ye
- Shabin Zhuang
- Zhiqing Chen (ORCID: https://orcid.org/0009-0006-1798-1222)
- Cailiang Cai
Institutions
- Dongguan University of Technology (CN)
- Dongguan People’s Hospital (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fphar.2025.1529525
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81