The eukaryotic elongation factor 2 kinase inhibitor, A484954, induces hypoglycaemic and hypotensive effects
We, for the first time, revealed that (1) A484954 caused hypoglycaemic effects through increasing urinary glucose excretion via decreasing SGLT2, (2) A484954 improved diabetic complication, including hypertension, through vasorelaxation and diuresis via NO production, and (3) A484954 had a positive inotropic effect.
Authors
- Hideyuki Yamawaki (ORCID: https://orcid.org/0000-0002-0053-9212)
- Muneyoshi Okada (ORCID: https://orcid.org/0000-0002-0746-206X)
- Tomoko Kodama (ORCID: https://orcid.org/0009-0003-7068-4460)
- Kosuke Otani (ORCID: https://orcid.org/0000-0001-6214-899X)
- Satoshi Kameshima (ORCID: https://orcid.org/0000-0003-2477-1750)
Institutions
- Kitasato University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1111/bph.17443
- Citations
- 2
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Kitasato University
- Japan Society for the Promotion of Science