Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission
Our results demonstrate that TLR4 activity influences the severity of ileitis, neuroglial plasticity, gut motility, and nitrergic and 5-HTergic neurotransmissions. The neuroimmune interaction between TLR4 and 5-HT observed in our study appears to be a potential pharmacological target to treat ENS dysfunction implicated in IBD onset/progression.
Authors
- Andrea Porzionato (ORCID: https://orcid.org/0000-0003-3025-4717)
- Cristina Giaroni (ORCID: https://orcid.org/0000-0002-3760-3441)
- Maria Cecilia Giron (ORCID: https://orcid.org/0000-0002-0825-7965)
- Silvia Cerantola (ORCID: https://orcid.org/0000-0001-7099-4475)
- Veronica Macchi (ORCID: https://orcid.org/0000-0003-2335-6897)
- Antonella Bertazzo
- Annalisa Bosi (ORCID: https://orcid.org/0000-0001-5027-880X)
- Sofia Faggin (ORCID: https://orcid.org/0000-0003-4813-2259)
- Edoardo Vincenzo Savarino (ORCID: https://orcid.org/0000-0002-3187-2894)
- Elena Stocco (ORCID: https://orcid.org/0000-0003-4572-622X)
- Valentina Caputi (ORCID: https://orcid.org/0009-0003-7699-702X)
- Alessandra Ponti
- Angela Tietto
Institutions
- University of Insubria (IT)
- Agricultural Research Service (US)
- United States Department of Agriculture (US)
- University of Padua (IT)
- University of Ferrara (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1111/bph.17439
- Citations
- 6
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.87
Funders
- Università degli Studi di Padova