Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis
PRL-1 expression in PD-MSCsPRL-1 restores TGFB1/BMP7 balance, promoting hepatic regeneration through mesenchymal-to-epithelial transition. These findings highlight the therapeutic potential of engineered MSCs for liver disease and suggest innovative strategies for future stem cell therapies.
Authors
- Se Ho Kim
- Gi Jin Kim (ORCID: https://orcid.org/0000-0002-2320-7157)
- Ki Seog Lee
- Hyeri Park (ORCID: https://orcid.org/0000-0003-2274-5313)
- Soo Young Park (ORCID: https://orcid.org/0000-0002-1469-2787)
- Jae Yeon Kim (ORCID: https://orcid.org/0000-0002-3457-5190)
- Ja Yun Lim
- Si Hyun Bae (ORCID: https://orcid.org/0000-0003-1727-7842)
Institutions
- Catholic University of Pusan (KR)
- Korea University (KR)
- Integrated Oncology (United States) (US)
- Korea Pharma (South Korea) (KR)
- EuBiologics (South Korea) (KR)
- CHA University (KR)
- Korea University (JP)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3350/cmh.2024.0741
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- National Research Foundation
- National Research Foundation of Korea
- CHA University
- Ministry of Science and ICT, South Korea