Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex
This study identifies a new signal valve through which TGF-β1 can inhibit osteogenesis specifically. Functional interruption of this valve can tilt the seesaw balance of BM-MSC differentiation towards osteogenesis, highlighting the interplaying co-repressors, such as HDAC1, as promising therapeutic targets to combat diverse degenerative orthopedic diseases.
Authors
- Ching‐Wei Luo (ORCID: https://orcid.org/0000-0003-3956-2935)
- Yingwen Wang (ORCID: https://orcid.org/0000-0003-2831-7926)
Institutions
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12964-025-02051-z
- Citations
- 2
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Shanghai Educational Development Foundation
- National Health Research Institutes
- National Science and Technology Council