Exercise therapy facilitates neural remodeling and functional recovery post-spinal cord injury via PKA/CREB signaling pathway modulation in rats
Our findings indicated that: (1) ET counteracted the H89-induced suppression of the PKA/CREB signaling pathway following SCI; (2) ET significantly alleviated neuronal injury and improved motor dysfunction; (3) ET facilitated neuronal regeneration by mediating the PKA/CREB signaling pathway; (4) ET enhanced synaptic and dendritic spine plasticity, as well as myelin sheath remodeling, post-SCI through the PKA/CREB signaling pathway.
Authors
- Junqing Huang (ORCID: https://orcid.org/0000-0001-7738-6093)
- Chang Jiang (ORCID: https://orcid.org/0000-0001-6417-2096)
- Shengcun Li (ORCID: https://orcid.org/0000-0002-2358-813X)
- Zhouguang Wang (ORCID: https://orcid.org/0000-0001-9903-0362)
- Zhiyi Feng
- Ping Wu (ORCID: https://orcid.org/0000-0002-0551-6300)
- Yanming Zuo
- Xinwang Ying (ORCID: https://orcid.org/0009-0008-0125-5538)
- Junpeng Xu (ORCID: https://orcid.org/0000-0001-6106-441X)
- Jiamen Shen (ORCID: https://orcid.org/0000-0002-1148-1685)
- Liuxi Chu (ORCID: https://orcid.org/0000-0002-6071-1870)
- Dawei Jiang
- Xiaokun Li (ORCID: https://orcid.org/0000-0002-1432-5573)
- Qingfeng Xie (ORCID: https://orcid.org/0000-0002-8692-6650)
- Yanfang Zhao (ORCID: https://orcid.org/0000-0003-4715-9046)
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Zhejiang Lab (CN)
- The First People's Hospital of Wenling (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1093/burnst/tkae058
- Citations
- 7
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Zhejiang Province