Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study
The current evidence indicates that a higher levels of C5aR2 significantly associated with better recovery, whereas high levels of C5a/C5aR2 significantly associated to poor prognosis in moderate to severe ARDS patients. However, adequately powered studies are required to confirm these findings in future.
Authors
- Vijayanarayana Kunhikatta
- Sreedharan Nair (ORCID: https://orcid.org/0000-0002-6076-3275)
- Vishal Shanbhag (ORCID: https://orcid.org/0000-0001-5255-6148)
- Vijetha Shenoy Belle (ORCID: https://orcid.org/0000-0003-3319-9661)
- Pooja Gopal Poojari (ORCID: https://orcid.org/0000-0001-6387-1012)
- Muhammed Rashid (ORCID: https://orcid.org/0000-0002-6390-7764)
- Girish Thunga (ORCID: https://orcid.org/0000-0003-1257-969X)
- Dev Vaz (ORCID: https://orcid.org/0000-0002-6725-2232)
- Viji Pulikkel Chandran
- Shravya Chitrapady
Institutions
- Manipal Academy of Higher Education (IN)
Publication Details
- Journal
- Heliyon
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1016/j.heliyon.2025.e42146
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Kasturba Medical College, Manipal
- Department of Science and Technology, Ministry of Science and Technology, India
- Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education