Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer’s disease: insights from machine learning analyses and WGCNA
This study is the first to use bioinformatics methods to identify ZDHHC22 as a key KPRG in AD, highlighting its potential role in disease diagnosis and immune regulation. The regulatory network of ZDHHC22 provides new insights into the molecular mechanisms of AD and lays the foundation for future targeted therapeutic strategies.
Authors
- Xiyao Zhao
- Sanying Mao
- Yilong Man
- Lei Wang (ORCID: https://orcid.org/0000-0002-0961-0441)
- Kaiyuan Li (ORCID: https://orcid.org/0009-0003-6370-1031)
Institutions
- Dalian Medical University (CN)
- The First People's Hospital of Changde (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s40001-025-02277-0
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49