Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients
In r-axSpA patients, circulating DN2 B cells are expanded and, together with transitional and naïve B cells, display significantly enhanced BCR signaling responses upon stimulation. Together, our data suggest B cell involvement in the pathogenesis of r-axSpA.
Authors
- Odilia B. J. Corneth (ORCID: https://orcid.org/0000-0002-8375-0506)
- Stefan F. H. Neys (ORCID: https://orcid.org/0000-0002-2083-6820)
- R. Wilbrink (ORCID: https://orcid.org/0000-0002-7865-6742)
- Gwenny M. Verstappen (ORCID: https://orcid.org/0000-0002-5682-6085)
- Rudi W. Hendriks (ORCID: https://orcid.org/0000-0003-2291-0382)
- Anneke Spoorenberg (ORCID: https://orcid.org/0000-0001-8850-8578)
- Frans G. M. Kroese (ORCID: https://orcid.org/0000-0003-3660-0617)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Erasmus MC (NL)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100270
- Citations
- 1
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek