Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipose tissue
ATF3 within the PVAT can modulate vascular function by strengthening sphingosine kinase 1 (sphk1)-S1P-S1P<sub>3</sub> receptor lipid signalling and stimulating S1P binding to HDL to form the vasodilator HDL-S1P. ATF3 is an essential modulator for maintaining the physiological function of PVAT, providing a novel target for treatment of obesity-related cardiovascular diseases.
Authors
- Heng Lin (ORCID: https://orcid.org/0000-0001-9332-3658)
- Tzu‐Ling Tseng (ORCID: https://orcid.org/0000-0002-8179-8557)
- Hsin‐Tzu Liu
- Tsung‐Jen Lin (ORCID: https://orcid.org/0000-0002-8017-6369)
- Hsiao‐Fen Li
Institutions
- Tzu Chi University (TW)
- Buddhist Tzu Chi General Hospital (TW)
- Hualien Tzu Chi Medical Center (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1111/bph.17433
- Citations
- 2
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Science and Technology Council
- Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation