Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence
In summary, this study presents a novel approach superior to recombinant protein alone and holds promise as a new therapeutic strategy for OA.
Authors
- Baixing Li
- Zanjing Zhai (ORCID: https://orcid.org/0000-0002-0312-7539)
- Wenxuan Fan (ORCID: https://orcid.org/0009-0007-0841-4581)
- Peixiang Ma (ORCID: https://orcid.org/0000-0001-6794-1663)
- Keyu Kong (ORCID: https://orcid.org/0000-0002-5839-6074)
- Huiwu Li (ORCID: https://orcid.org/0000-0002-2084-2737)
- Yansong Qi (ORCID: https://orcid.org/0000-0003-1764-493X)
- Hua Qiao
- Yongyun Chang (ORCID: https://orcid.org/0000-0001-7191-9573)
- Liao Wang (ORCID: https://orcid.org/0000-0001-6573-7677)
- Minghao Jin (ORCID: https://orcid.org/0000-0002-6790-8860)
- Xinru Wu (ORCID: https://orcid.org/0000-0002-9097-265X)
- Chen Zhao (ORCID: https://orcid.org/0000-0001-7323-8237)
- Yongsheng Xu (ORCID: https://orcid.org/0000-0002-5922-0564)
Institutions
- Shanghai Ninth People's Hospital (CN)
- Inner Mongolia People's Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12951-025-03103-9
- Citations
- 18
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 30.03
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- Fundamental Research Funds for the Central Universities
- Program of Shanghai Academic Research Leader