Isolated congenital diaphragmatic hernia and three-year neurodevelopmental outcomes
This research highlights the observed/expected lung area-to-head circumference ratio (o/e LHR) as a crucial indicator to predict neurodevelopmental outcomes in 3-year-old children diagnosed with isolated congenital diaphragmatic hernia (CDH). Our results provide robust evidence from a large multicenter cohort, emphasizing the importance of o/e LHR in early risk stratification and prolonged neurodevelopmental follow-up. These findings highlight the need for comprehensive management and tailored follow-up care in CDH patients, potentially improving clinical protocols and enhancing the quality of life and outcomes for affected children.
Authors
- Shoichiro Amari (ORCID: https://orcid.org/0000-0003-4750-513X)
- Kiyokazu Kim (ORCID: https://orcid.org/0000-0002-3522-0826)
- Hirosato Aoki (ORCID: https://orcid.org/0000-0002-8558-7693)
- Miharu Ito (ORCID: https://orcid.org/0000-0001-7012-5974)
- Hiroomi Okuyama (ORCID: https://orcid.org/0000-0002-1347-282X)
- Katsuaki Toyoshima (ORCID: https://orcid.org/0000-0002-7817-9907)
- Takuya Kondo (ORCID: https://orcid.org/0000-0003-2873-2417)
- Kouji Nagata (ORCID: https://orcid.org/0000-0002-8933-8889)
- Hitomi Arahori
- Keita Terui (ORCID: https://orcid.org/0000-0003-4315-5179)
- Hirosuke Inoue (ORCID: https://orcid.org/0000-0002-5804-8053)
- Hidehiko Maruyama (ORCID: https://orcid.org/0000-0003-1008-5071)
- Masaya Yamoto (ORCID: https://orcid.org/0000-0001-6660-362X)
- Noriaki Usui (ORCID: https://orcid.org/0000-0003-1498-1762)
- Kaoru Katsumata
- Yoshiaki Sato (ORCID: https://orcid.org/0000-0001-6320-9176)
- Tomoko Saito (ORCID: https://orcid.org/0000-0001-7179-0765)
Institutions
- Kyushu University (JP)
- Jichi Medical University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Nagoya University Hospital (JP)
- Osaka Women's and Children's Hospital (JP)
- Kanagawa Children's Medical Center (JP)
- National Center For Child Health and Development (JP)
- Shizuoka Children's Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1038/s41390-025-03870-z
- Citations
- 3
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Ministry of Health, Labour and Welfare