Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells
lidocaine was cytotoxic to Hep-2 cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. The results of this study offered initial optimism that lidocaine could be used in an adjuvant or neoadjuvant fashion in cancer treatment.
Authors
- Meihong Lv
- Yi Yu (ORCID: https://orcid.org/0000-0001-5598-6848)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8920-1172)
- Yi He (ORCID: https://orcid.org/0009-0009-5507-7906)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12885-025-13533-1
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Department of Education of Liaoning Province
- Dalian Medical University