The Impact of Liver Graft Preservation Method on Longitudinal Gut Microbiome Changes Following Liver Transplant: A Proof-of-concept Study
Fecal microbiota alterations associated with end-stage liver disease do not fully normalize to a healthy control profile following liver transplantation. However, notable differences in microbiota composition and function were observed between liver graft preservation methods. Future research with larger randomized cohorts is needed to explore whether the NMP-associated shift in gut microbiota impacts clinical outcomes and if breath VOCs could serve as biomarkers of the clinical trajectory in liver transplant patients.
Authors
- Darren Liu
- Luca Del Prete (ORCID: https://orcid.org/0000-0003-0268-3266)
- Koji Hashimoto (ORCID: https://orcid.org/0000-0001-8024-0060)
- David Grove (ORCID: https://orcid.org/0000-0002-0496-9746)
- Beatrice Cazzaniga (ORCID: https://orcid.org/0000-0002-3180-9078)
- Khaled Ali (ORCID: https://orcid.org/0000-0002-9114-897X)
- Cristiano Quintini (ORCID: https://orcid.org/0000-0002-6802-1436)
- David Shapiro (ORCID: https://orcid.org/0000-0002-8667-8861)
- Gail Cresci (ORCID: https://orcid.org/0000-0002-5717-7099)
- Charles Miller (ORCID: https://orcid.org/0000-0002-6168-259X)
- Naseer Sangwan (ORCID: https://orcid.org/0000-0002-2407-769X)
- Qiang Liu
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Digestive Care (United States) (US)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.14218/jcth.2024.00352
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cleveland Clinic
- Lerner Research Institute, Cleveland Clinic