Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia
Intensive care patients with severe preeclampsia have lower plasma S1P levels and higher concentrations of glycocalyx degradation products, indicating more pronounced endothelial damage. These findings suggest that S1P is associated with preeclampsia severity and may serve as a biomarker to assess vascular damage in this patient population. Further studies are needed to explore the potential role of S1P in long-term cardiovascular risk assessment for patients with preeclampsia.
Authors
- Lotte Vanherle (ORCID: https://orcid.org/0000-0002-4864-1347)
- Frank Matthes (ORCID: https://orcid.org/0000-0002-5115-8831)
- Lena Erlandsson (ORCID: https://orcid.org/0000-0003-4350-5909)
- Anja Meißner (ORCID: https://orcid.org/0000-0002-0793-7213)
- Federica Piani (ORCID: https://orcid.org/0000-0003-3338-1172)
- Stefan R. Hansson (ORCID: https://orcid.org/0000-0002-7838-9074)
- Camilla Edvinsson (ORCID: https://orcid.org/0000-0002-0825-7260)
Institutions
- University of Augsburg (DE)
- Lund University (SE)
- Wallenberg Wood Science Center (SE)
- Helsingborgs lasarett (SE)
- Skåne University Hospital (SE)
- University of Bologna (IT)
Publication Details
- Journal
- Hypertension
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1161/hypertensionaha.124.24118
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23
Funders
- Lunds Universitet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet