Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension
Our findings highlight that lack of short-chain fatty acid-receptor signaling via both GPR41 and GPR43 increases risk of high blood pressure, suggesting treatments that target these receptors could be a novel strategy to prevent or treat hypertension.
Authors
- David M. Kaye (ORCID: https://orcid.org/0000-0003-4058-0372)
- K. Leung (ORCID: https://orcid.org/0000-0002-2998-9807)
- Maria Kaparakis‐Liaskos (ORCID: https://orcid.org/0000-0002-8964-4456)
- Joanne A. O’Donnell (ORCID: https://orcid.org/0000-0002-8434-1050)
- Michael Nakai (ORCID: https://orcid.org/0000-0002-6400-8007)
- Katrina M. Mirabito Colafella (ORCID: https://orcid.org/0000-0002-9181-9040)
- Zoe McArdle (ORCID: https://orcid.org/0000-0001-8279-6222)
- Francine Z. Marques (ORCID: https://orcid.org/0000-0003-4920-9991)
- Chad A. Johnson (ORCID: https://orcid.org/0000-0002-9304-5448)
- Evany Dinakis
- Tenghao Zheng (ORCID: https://orcid.org/0000-0003-1587-7481)
- Rikeish R. Muralitharan (ORCID: https://orcid.org/0000-0002-7577-2123)
- Charles R. Mackay (ORCID: https://orcid.org/0000-0002-6338-7340)
- Ekaterina Salimova
- Natalie J. Bitto (ORCID: https://orcid.org/0000-0003-3533-9824)
- Anastasia Barbaro-Wahl (ORCID: https://orcid.org/0009-0001-1058-7824)
- Liang Xie (ORCID: https://orcid.org/0009-0001-0973-8402)
- Wendy Qin
- Hamdi Jama
- Madeleine Patterson
Institutions
- Mental Health Research Institute (AU)
- Baker Heart and Diabetes Institute (AU)
- Qilu University of Technology (CN)
- The University of Melbourne (AU)
- National University of Singapore (SG)
- La Trobe University (AU)
- Discovery Institute (US)
- The Alfred Hospital (AU)
- Shandong Academy of Sciences (CN)
- Monash University (AU)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1161/circresaha.124.325770
- Citations
- 35
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 27.40