Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification
Dysregulated mineral metabolism drives changes in the epigenetic landscape and nuclear lamina dysfunction that together promote early induction of inflammaging pathways priming the vasculature for downstream pathological change.
Authors
- Lilia Draganova (ORCID: https://orcid.org/0000-0003-1371-104X)
- Rukshana Shroff (ORCID: https://orcid.org/0000-0001-8501-1072)
- Jirapath Thammaphet (ORCID: https://orcid.org/0000-0002-4680-9214)
- Anja Verhulst (ORCID: https://orcid.org/0000-0002-4533-443X)
- Sadia Ahmad (ORCID: https://orcid.org/0000-0002-6206-6764)
- Umesh S. Jonnalagadda (ORCID: https://orcid.org/0000-0002-4715-4993)
- Catherine M. Shanahan (ORCID: https://orcid.org/0000-0002-8352-8171)
- Wilson Lek Wen Tan (ORCID: https://orcid.org/0000-0002-5054-8512)
- Roger Foo (ORCID: https://orcid.org/0000-0002-8079-4618)
- Robert Hayward
- Mengying Wu (ORCID: https://orcid.org/0000-0002-9463-9870)
- Chin Yee Ho (ORCID: https://orcid.org/0000-0001-7413-4288)
- Grace Anderson (ORCID: https://orcid.org/0000-0001-6374-1445)
- Johnson Fred S.
Institutions
- University of Antwerp (BE)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- Great Ormond Street Hospital (GB)
- British Heart Foundation (GB)
- University College London (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1161/circresaha.124.325374
- Citations
- 9
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 7.25