Intermittent Fasting Ameliorates β‐Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model
Our findings demonstrate that IF ameliorates amyloid deposition and cognitive deficits in the AD model mice, which is associated with the reduction of LDs within microglia, providing support for the use of the dietary intervention against AD pathology.
Authors
- Xiaokang Gong (ORCID: https://orcid.org/0000-0002-0101-4944)
- Zheng Liang (ORCID: https://orcid.org/0009-0008-3006-2727)
- Jing Yu (ORCID: https://orcid.org/0000-0001-7371-4512)
- Jian Bao (ORCID: https://orcid.org/0000-0003-2869-8415)
- Yuheng Zhang (ORCID: https://orcid.org/0009-0009-2457-0976)
- Xiji Shu (ORCID: https://orcid.org/0000-0002-7415-6230)
- Xiaochuan Wang (ORCID: https://orcid.org/0000-0001-8207-0042)
- Liangwei Wu (ORCID: https://orcid.org/0009-0007-0641-8917)
- Jiaquan Wang (ORCID: https://orcid.org/0000-0002-7201-8467)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-4203-2003)
Institutions
- Jianghan University (CN)
- Ningxia Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Nutrition & Food Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1002/mnfr.202400660
- Citations
- 5
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province