Electrosynthesis of Fluoroalkenes from Alpha‐CF<sub>3</sub> and Alpha‐CF<sub>2</sub>H Benzyl Halides
We have developed an efficient synthesis of fluoroalkenes via tandem electrochemical dehalogenation-elimination protocol. The key step is the generation of carbon anion by electrochemical reductive dehalogenation of alkyl halides. Various gem-difluoroalkenes and monofluoroalkenes were prepared in moderate to good yields from α-difluoromethylated/α-trifluoromethylated benzyl halides.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8702-1872)
- Shiyu He (ORCID: https://orcid.org/0000-0003-2383-2072)
Institutions
- Donghua University (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1002/chem.202404449
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00