Short-Term Outcomes of Dual Versus Single Antiplatelet Therapy Following Popliteal and Infrapopliteal Endovascular Therapy: Data From Dutch Chronic Lower Limb-Threatening Ischemia Registry (THRILLER)
This manuscript reports on the efficacy and safety outcomes of 3 months of DAPT versus SAPT, which are commonly chosen therapies following popliteal and infrapopliteal endovascular therapy. No significant difference was found between the two groups regarding major adverse cardiovascular events, all-cause death, major amputation, or major bleeding. Therefore, 3 months of DAPT does not seem superior to SAPT. These results suggest that SAPT appears to be a sufficient alternative when considering 3 months of DAPT. Further research should verify these outcomes and focus on the efficacy and safety of prolonged DAPT suppletion after endovascular therapy.
Authors
- Constantijn E.V.B. Hazenberg (ORCID: https://orcid.org/0000-0002-2408-2720)
- Çağdaş Ünlü (ORCID: https://orcid.org/0000-0001-6716-4016)
- Daniël A. F. van den Heuvel (ORCID: https://orcid.org/0000-0002-6515-417X)
- Gert J. de Borst (ORCID: https://orcid.org/0000-0002-1389-4141)
- Jan-Willem Hinnen (ORCID: https://orcid.org/0000-0001-5896-7984)
- M.E. Pierie (ORCID: https://orcid.org/0000-0002-3690-3426)
- Bram Fioole (ORCID: https://orcid.org/0000-0001-9945-910X)
- Olaf J. Bakker (ORCID: https://orcid.org/0000-0001-6666-7631)
- Olaf Schouten (ORCID: https://orcid.org/0000-0002-6746-4673)
- G.P. Akkersdijk
- Michiel A. Schreve (ORCID: https://orcid.org/0000-0002-7923-6387)
- M.K. Dinkelman
- Jan M.M. Heyligers (ORCID: https://orcid.org/0000-0002-7450-9622)
- Michael J. Nugteren (ORCID: https://orcid.org/0000-0003-2154-4077)
- Emilien C. J. Wegerif (ORCID: https://orcid.org/0000-0002-9849-439X)
- Bart A.N. Verhoeven
- Isa F. van Galen
Institutions
- University Medical Center Utrecht (NL)
- Northwest Hospital (US)
- St. Antonius Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Isala (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Jeroen Bosch Ziekenhuis (NL)
Publication Details
- Journal
- Journal of Endovascular Therapy
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1177/15266028241312356
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00