Retrospective study on thyroid function modifications in patients diagnosed with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a complex endocrine condition, and its association with thyroid dysfunction is variably reported in the literature.The aim of the study was to retrospectively evaluate the degree of association between PCOS and thyroid impairment in a cohort of 269 patients.Materials and methods: The study had a retrospective observational design.The data were analyzed descriptively and using a multivariate logistic regression model to an alyze the association between thyroid status and the type of thyroid disorder with each PCOS phenotype individually.The results were reported as relative risk ratios (RRR) and 95% confidence intervals (CI).Results: The presence of phenotype A in the context of advanced age increased the risk of developing hyperthyroidism by 9% (RRR: 1.06, 95% CI: 1.01 -1.12, p=0.019), while in the context of a normal or low BMI, it decreased the risk of developing hyperthyroidism by 93% (RRR: 0.07, 95% CI: 0.08-0.68,p=0.021).Phenotype B in the context of a normal or low BMI increased the risk of developing hyperthyroidism by over 15 times (RRR: 15.86, p=0.03).Conclusions: Early identification of thyroid abnormalities in patients with PCOS is warranted and requires an individualized therapeutic approach.