Relationships between clinical manifestations and histopathological features in endometriosis: implications for precision diagnosis and treatment

Endometriosis is a chronic inflammatory di sease affecting reproductive-age women, often associated with pain and infertility.Aim: This study aims seeks to investigate the relationships between clinical and paraclinical present ations, and histopathological features in endometriosis, with the objective of improving dia gnostic accuracy and guiding personalized treatment strategies.Materials and methods: A prospective study was carried out involving 40 patients evaluated at "Cuza -Vod" and "Elena-Doamna" Obstetrics and Gynecology Clinical Hospitals, Iasi, between September 2019 to August 2024, of whom 40 met the inclusion criteria.Key clinical data and biomarker levels, including CA-125, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte ratios (PLR) and systemic immune inflammation index (SII) were analyzed for correlations with histopathological findings, as well as with rASRM staging and the EFI index.Results: Compared to the control group, the association of elevated CA-125 levels with systemic inflammatory markers (NLR, PLR, SII) highlights the chronic inflammatory process characte ristic of this pathology.In terms of systemic inflammatory markers, the rASRM classification identifies lower values in stage IV compared to stage III, while the EFI classification does not reveal any significant changes.Conclusions: The study highlights the importance of correlating clinical and histopathological data in endometriosis for a more nuanced staging and personalized treatment approach.The association of CA-125, systemic inflammatory markers, and rASRM staging may provide the foundation for the identification of novel noninvasive biomarkers, as well as potential prognostic factors for endometriosis.