Evaluation of anti-inflammatory activity of nitro-L-arginine methyl ester derivatives with thiazolidin-4-one scaffold

This paper is focused on the evaluation of the anti-inflammatory potential of some novel nitro-Larginine methyl ester derivatives with thiazolidin-4-one structure, synthesized by our research group.Materials and methods: The evaluation of the anti-inflammatory potential was performed using in vitro assays: human red blood cell membrane stabilization (HRBC) and inhibiting bovine serum albumin denaturation (BSA) assays.Results: The obtained results showed that both stability of the erythrocyte membrane and inhibition of bovine serum albumin (BSA) denaturation, as parameters of anti-inflammatory effect evaluation, depend on the structure and concentration of the tested compounds.The most active derivatives were the compounds in which the aromatic ring from 2-position of thiazolidine-4-one scaffold is unsubstituted (2a) and halogen-substituted (with 4-chloro -2c, and 4-bromo-2e).Conclusions: The most favorable influence was obtained by the aromatic substitution wit h chloro and bromo in para position, the corresponding derivatives being the most active derivatives compared to diclofenac, used as anti-inflammatory standard.