TNFα Therapy – Is Personalization of Treatment Selection Possible?

TNF-α is a important inflammatory protein, involved in the pathogenesis of many immune-mediated diseases. It activates various cellular processes, including inflammation, cell death, and the production of other inflammatory molecules. TNF-α Interacts with two Types of Receptors (TNFR1 and TNFR2), triggering different cellular responses. Activation of TNFR1 typically leads to inflammation, while TNFR2 may have anti-inflammatory effects. Elevated levels of TNF-α are associated with many autoimmune diseases, such as rheumatoid arthritis and psoriasis.