Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study

Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8-10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.

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Publication Details

Journal
Neurobiology of Disease
Published
2025-01-23
DOI
https://doi.org/10.1016/j.nbd.2025.106807
Citations
3
Primary Topic
EEG and Brain-Computer Interfaces
Type
article
Field-Weighted Citation Impact
4.29

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article

Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study

İlayda Kıyı, Roberta Lizio, Matteo Carpi, Giuseppe Bruno et al.
3 citations
Neurobiology of Disease
EEG and Brain-Computer Interfaces
4.29
article

Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study

İlayda Kıyı, Roberta Lizio, Matteo Carpi, Giuseppe Bruno, Laura Vacca, Raffaele Ferri, Chiara Coletti, Anita D’Anselmo, Sofia Cuoco, Claudio Babiloni, Lütfü Hanoğlu, Fabrizio Stocchi, Franco Giubilei, Giuseppe Noce, Claudio Del Percio, Francesca De Pandis, Francesco Famà, Giovanni Battista Frisoni, Angelo Antonini, Yağmur Özbek, Bartolo Lanuzza, Laura Bonanni, Rossella Rotondo, Dharmendra Jakhar, Susanna Lopez, Fabrizia D’Antonio, Federico Massa, Nesrin Helvacı Yılmaz, Paolo Barone, Bahar Güntekin, Matteo Pardini, Marco Salvatore, Görsev Yener, Roberta Biundo, Moira Marizzoni, Dario Arnaldi, Burcu Bölükbaş, John‐Paul Taylor, Andrea Soricelli, Michele Salerni
article en
3 citations

Abstract

Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8-10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.

Neurobiology of DiseaseVol. 206
University of Salerno (IT), Izmir University (TR), University of Padua (IT), Parthenope University of Naples (IT), Università degli studi di Cassino e del Lazio Meridionale (IT), Dokuz Eylül University (TR), San Raffaele University of Rome (IT), Istanbul Medipol University (TR), University of Chieti-Pescara (IT), Oasi Maria SS (IT), Centro San Giovanni di Dio Fatebenefratelli (IT), IRCCS Ospedale San Raffaele (IT), Ospedale Policlinico San Martino (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), Newcastle University (GB), Sapienza University of Rome (IT)
Università degli Studi di Padova, Sapienza Università di Roma, Università degli Studi di Genova, Università degli Studi G. d'Annunzio Chieti - Pescara, IRCCS San Raffaele Pisana
Gender equality
Openalex Percentile: Top 7%
EEG and Brain-Computer Interfaces
4.29
DOIOpen Access PDFOpenAlex
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