Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity
Overall, we have developed two promising new mouse models that are suitable for preclinical studies of MASLD as they recapitulate most of the key features of MASLD.
Authors
- Konstantinos Iordanidis
- Michael P. Manns (ORCID: https://orcid.org/0000-0002-4485-8856)
- Ludwig Wilkens
- Heiko Schenk (ORCID: https://orcid.org/0000-0003-2693-5712)
- F Becker
- Janine Dywicki
- Silke Marhenke
- Richard Taubert (ORCID: https://orcid.org/0000-0001-9270-2496)
- Elmar Jaeckel (ORCID: https://orcid.org/0000-0003-4108-7192)
- Young‐Seon Mederacke (ORCID: https://orcid.org/0000-0002-2653-9106)
- Katharina Luise Hupa‐Breier (ORCID: https://orcid.org/0000-0002-8372-616X)
- Alejandro Campos-Murguía (ORCID: https://orcid.org/0000-0002-2178-302X)
- Benjamin Heidrich (ORCID: https://orcid.org/0000-0002-0213-3873)
- Maren Lieber
- K. Lenhard Rudolph (ORCID: https://orcid.org/0000-0002-4839-2862)
- Freya Wellhöner (ORCID: https://orcid.org/0000-0002-9031-2731)
- Fatih Noyan (ORCID: https://orcid.org/0000-0001-6250-8692)
- Heiner H. Wedemeyer (ORCID: https://orcid.org/0000-0003-2906-0480)
- Matthias Hardtke‐Wolenski (ORCID: https://orcid.org/0000-0002-2827-7787)
- Clara Böker
- Christoph Terkamp
- Julian W. Mall
- Björn Hartleben
- Hanna Redeker
Institutions
- University Health Network (CA)
- Medizinische Hochschule Hannover (DE)
- KRH Klinikum Nordstadt (DE)
- Essen University Hospital (DE)
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1016/j.molmet.2025.102104
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Leibniz-Gemeinschaft