Analysis on the Anti-obesity Mechanism of Warm Drugs Based on "Yang Leading to Qi and Yin Leading to Formation"

Obesity has become one of the major health problems threatening people's health in the 21st century, the mechanism of which is the accumulation of lipid in the body caused by energy intake exceeding energy consumption. Traditional Chinese medicine has attracted attention because of its multi-target and multi-pathway treatment characteristics. Traditional Chinese Medicine believes that the fundamental pathogenesis of obesity lies in the insufficiency of both the spleen and the kidney in essence, accompanied by full of phlegm-damp. "Those who suffer from phlegm fluid should be treated with warm drugs", recorded in Jinkui yaolue. The warm drugs, which functions based on "yang leading to qi and yin leading to formation", should be used to improve the basic metabolic rate of the body, improve the function of the viscera, promote gene expression in adipose tissue, reduce insulin resistance, regulate cholesterol metabolism and improve the intestinal microbial ecosystem to achieve anti-obesity effects.