Genetic factors affecting skin health

Skin is the largest organ in the human body, performing a barrier function to maintain homeostasis of the body. Skin aging is a complex process influenced by hereditary and environmental factors. Properties such as hydration, elasticity and antioxidant capacity play a key role in the skin aging process. Genetic variations can affect the production of collagen and elastin, the level of antioxidants and the integrity of the barrier function of the skin. Identification of genetic markers that affect skin condition will allow us to develop recommendations for correcting signs of aging, and may also become an effective and affordable method for treating many skin diseases in the future. This review summarizes and presents current data on genetic factors and molecular mechanisms affecting the health and appearance of the skin. Keywords: skin, genes, polymorphism, dermatology, cosmetogenetics