Subcutaneous Panniculitis-Like T-Cell Lymphoma in Two Dogs with Indolent Progression, As A Clinical and Histopathological Form of Non-Epitheliotropic Lymphoma

The subcutaneous panniculitis-like form of non-epitheliotropic T-cell lymphoma (SPTCL) has previously been described in dogs and is generally associated with poor prognosis. We describe two cases that showed a slow and benign progression, similar to the a-b T-cell phenotype without haemophagocytic syndrome form of the disease observed in humans. In contrast to the more aggressive g-d phenotype, the T-cells involved in this form of SPTCL in humans are CD30- and CD56-, as seen in the present cases, highlighting their potential as prognostic markers for a better outcome also in dogs.