Features of the ultrastructural organization of endothelial cells of the capillaries of the mammalian cerebral cortex, using the example of a domestic bull

There are many tissue barriers in the body, the work of which is largely due to the structure of the vascular wall of the capillary bed. Each of them has its own structural organization, which determines the characteristics of the transport of substances. Many pathologies are caused by a violation of their permeability, associated with changes in the composition of the interstitial medium. That is why the study of the features of the organization of histogematic barrier structures is not only theoretical, but also extremely important in practice. Considering the above, the goal was set to establish the features of the ultrastructural organization of the endothelial cells of the capillaries of the mammalian cerebral cortex, using the example of a domestic bull. The study was carried out using the technique of electron microscopy. The material was fragments of the cerebral cortex of a domestic bull. Their processing for the production of ultrathin sections was carried out according to generally accepted methods. The sections were contrasted with a 2.0% aqueous solution of uranyl acetate and a solution of lead citrate. Photos of ultrathin sections were obtained using the Jem1011 electron microscope (JEOL, Japan) at magnifications of 2500-3000. The terms given in the work correspond to the International Histological Nomenclature. It has been established that the endotheliocytes of the capillaries of the mammalian cerebral cortex are low-profile cells with a polygonal shape. One large spherical core is revealed in their composition. Heterochromatin in the composition of the latter occupies the peripheral zone, due to which its central part remains electron-luminous. A small volume of cytoplasm surrounds the cell nucleus with a thin layer. It contains a small number of organelles and a small number of pinocytic vesicles, which indicates low cell transport activity.