Evaluation of the efficacy of microbial strains in vaccines for the prevention of salmonellosis in animals

Animal salmonellosis is an infectious disease affecting a wide range of productive animals. Vaccination of animals is one of the effective ways to combat salmonellosis and remains in demand in veterinary practice. On the territory of the Russian Federation more than 30 vaccines against salmonellosis in animals are used. Conventionally, means of specific immunoprophylaxis against salmonellosis can be divided into two groups: vaccines against avian salmonellosis and vaccines against salmonellosis of other animal species. Production strains are usually derived from isolates isolated from animals in salmonellosis epizootics in the vaccineproducing countries. Inactivated vaccines against avian salmonellosis, represented by preparations, mainly, of foreign manufacturers are made on the basis of cultures obtained from strains of S. Enteritidis, S.Typhimurium and S.Infantis, which corresponds to the etiological structure of animal and human salmonellosis morbidity. Among the means of immunoprophylaxis of salmonellosis in cattle and pigs, used in the territory of the Russian Federation, there are no preparations of foreign manufacturers, and the etiological structure of the disease in these species of animals for many years remains unchanged. Domestic vaccines are developed on the basis of production strains, reference samples of which are deposited in the relevant state collections, the updated list of which is approved by the Order of the Government of the Russian Federation from 06.09.2021 № 2460-r. The majority of vaccines against salmonellosis in animals, excluding birds, used in the territory of the Russian Federation are made on the basis of S. choleraesuis strains. Choleraesuis 370, S. Typhimurium 371 and S. Dublin 373, selected in FGBU "VGNKI", which indicates their sufficient efficiency and epizootic significance at present.