Features of Nf-kb expression in the inner pyramidal layer of the motor cortex of rats with experimental type 1 diabetes mellitus

The aim of our study is to characterize the peculiarities of Nf-kb expression in the inner pyramidal layer of the motor cortex of the brain in experimental type 1 diabetes mellitus (DM 1). The study was performed on 5 groups of animals, each group included 10 female rats at 12 months of age. Immunohistochemical study of the inner pyramidal layer of the motor cortex revealed the following differences between the intact and untreated type 1 DM groups: in the untreated type 1 DM group, Nf-kb IRM expression was observed predominantly in the nuclei of damaged neurons in the form of clumps, while in the intact group – in the cytoplasm of intact perikaryons. In the intact group, IRM expression was detected in vertically located axons of neurons, while in the untreated type 1 DM group, no Nf-kb expression was detected in vertical segments. Specific changes were also observed in the pharmacorrection group: the pattern of immunohistochemical characterization of the aminalone, succicardium group was more in line with that of the intacta group. In the group of pharmacorrection with mefargin the picture was similar to the picture of type 1 DM without treatment.