Allostasis: genesis and allostatic load

A search for information in open sources of scientific literature was carried out to understand the phenomenon of allostasis and study the influence of allostatic load on the human body. Allostasis is considered in comparison with general adaptation syndrome and chronic stress. The article discusses the possibility of differentiating the allostatic state depending on its genesis: physiologically determined allostasis and clinically determined allostasis. The boundary between physiologically and clinically determined allostasis is determined by the allostatic load. The search for informative biomarkers of the allostatic state and the calculation of the allostatic load index open up promising opportunities for managing the adaptation process and developing preventive measures to optimize the functional state of the body and improve human performance.