Microcirculatory changes in the mucous membrane of the cervix in women with isthmic-cervical insufficiency

Relevance: An increase in the incidence of women with isthmic-cervical insufficiency dictates the need to improve existing therapies taking into account developing changes, including in the microcirculatory bed of the cervix. In the form of a diverse number of predictor factors, the clinician is faced with the task of choosing and justifying an approach to prescribing drug therapy. One of the initial changes is a violation of the microcirculation system, the identification of which served as the purpose of this work. Materials and methods: A survey of local blood flow in women with isthmic-cervical insufficiency was conducted, for a comparative analysis of the results obtained, the nature and type of microcirculation in healthy women of a similar age group were determined. Disorders in the microcirculatory bed were carried out in two stages – determination of the microcirculation parameter, the mean square deviation and the coefficient of variation. At the second stage, the contribution of active and passive oscillations to the overall modulation of blood flow was determined by the Wavelet transform method. Results: The data obtained indicate the development of a mild degree of microcirculation insufficiency, an increase in the contribution of pulse and respiratory waves to the overall spectrum of modulations due to a decrease in endothelial flaxmotion. Conclusion: A certain complex of microcirculatory disorders has been identified, associated with both structural changes in microvessels and rheological shifts and deterioration of barrier function.