Effects of a new GABA derivative with anxiolytic and antidepressant actions on sexual behavior, fertility, and the development of products of conception

In experiments on adult rats, females studied the effect of a new derivative of GABA – citrocard (citrate of 4-amino-3-phenylbutanoic acid) on sexual behavior and fertility. Citrocard in doses of 50 mg/kg (experimentally proven therapeutic dose) and 700 mg/kg (dose exceeding the therapeutic 14 times) was administered intragastrically to female rats for 2 weeks. It was established that after the introduction of sexual behavior in rats of females receiving a citrocard at a dose of 50 mg/kg, the duration of sexual activity did not change relative to the control, but the ability to mate with males was clearly increased (“emotional” approaches and lordoses increased by 43,8 % (p 0.01) and 30.4 % (p 0.05)), respectively. In females treated with a citrocard at a dose of 700 mg/kg, the duration of sexual activity decreased slightly, but their receptive ability was higher than the control values (the number of lordoses indicating their readiness for mating increased by 17.4 % (p 0,05). It was also revealed that when mating with intact males in rats of females previously treated with a citrocard 2-week course, fertility processes and fertility rates increased. Relative to control, in females of the experimental groups, the pregnancy index increased, by 4.8% (p 0.05) and 33.3 % (p 0.05), respectively, in doses and fertility, by 4.2% (p 0 05) and 19.0% (p 0.05), as well as their overall fetal death rates decreased, both preimplantation and postimplantation.