The Role of Nur77 in Glucose Metabolism Regulation: Implications for ARDS Pathophysiology

Nur77 (Neuron-derived clone 77) is one of the members of the orphan nuclear receptor family, and its expression and activation are rapidly triggered under a variety of physiological and pathological stimuli and have complex biological activities. Studies indicate that Nur77 regulates glucose metabolism in a tissue-dependent manner, and this mechanism may play a role in the occurrence and progression of acute respiratory distress syndrome (ARDS). Understanding how Nur77 regulates glucose metabolism and how it influences the onset and progression of ARDS is expected to provide an opportunity to alter Nur77 to regulate glucose metabolism and explore novel targets for ARDS medication therapy. In this review, we will discuss the molecular biological functions and expression of Nur77, the regulation of glucose metabolism by Nur77, and its putative role in ARDS.