Receptor activity-modifying protein 1 regulates the differentiation of mouse skin fibroblasts by downregulating α-SMA expression via suppression of high mobility group AT-hook 1 to promote skin wound repair
Our findings suggest that RAMP1 OE decreases differentiation and promotes migration in MSFs by downregulating α-SMA expression via the suppression of HMGA1 and modulates ECM synthesis and remodeling, revealing a novel mechanism regulating α-SMA transcription, providing new insights into the RAMP1-mediated regulation of fibroblast function, and identifying effective nerve-related targets for skin wound repair.
Authors
- Guoqi Cao
- Rui Sun (ORCID: https://orcid.org/0000-0001-9561-7932)
- Jiaxu Ma
- Zhenjie Wu (ORCID: https://orcid.org/0000-0003-1888-8469)
- Yongpan Lu
- Chunyan Liu (ORCID: https://orcid.org/0000-0001-8274-0747)
- Jian Liu (ORCID: https://orcid.org/0000-0002-1447-0973)
- Yibing Wang (ORCID: https://orcid.org/0000-0002-0012-4455)
- Siyuan Yin (ORCID: https://orcid.org/0009-0007-1429-4547)
- Ru Song (ORCID: https://orcid.org/0009-0009-8719-6512)
- Linqi Su
Institutions
- Shandong University (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1093/burnst/tkae068
- Citations
- 6
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Key Technology Research and Development Program of Shandong