Organocatalytic Cascade Reactions for the Synthesis and Diversification of Privileged Structures

Herein, we present the development of new organocatalytic cascade reactions for the synthesis and diversification of privileged structures, using trienamine activation as a key step. An important feature of this process is that once it is completed, it is possible to generate new reactive species within the same molecule. In this sense, a series of consecutive reactions can be carried out, incorporating dienophiles with a nucleophilic addition functionality. As a result, complex and diverse compounds can be accessed through simple starting materials.