Synthesis of Borylated Amidines Based on Closo-Dodecaborate Anion and Sulfur-Containing Amino Acids
IA new method for synthesizing boronated amidines based on amino acids of the type [B12H11NHC(NHCHR'COOH)R]– has been developed, which significantly increases the yield of target compounds. The process of obtaining conjugates of the closo-dodecaborate anion and sulfur-containing amino acids was studied. These derivatives show high potential for the development of new agents for BNCT (boron neutron capture therapy) based on boron-coated gold nanoparticles containing vector groups conjugated through peptide synthesis methods.
Authors
- К. Yu. Zhizhin (ORCID: https://orcid.org/0000-0002-4475-124X)
- N. K. Neumolotov (ORCID: https://orcid.org/0000-0002-8786-624X)
- А. V. Nelyubin (ORCID: https://orcid.org/0000-0002-9990-4231)
- А. P. Zhdanov
- Н. Т. Кузнецов (ORCID: https://orcid.org/0000-0002-2562-6427)
- Н. А. Селиванов (ORCID: https://orcid.org/0000-0001-7426-5982)
- A. Yu. Bykov (ORCID: https://orcid.org/0000-0003-1793-8487)
- М. N. Ryabchikova
Institutions
- National Research University Higher School of Economics (RU)
- NS Kurnakova Institute of General and Inorganic Chemistry (RU)
Publication Details
- Journal
- Russian Journal of Inorganic Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s0036023624603556
- Citations
- 1
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.40