Protective Effect of Korean Native Bee-honey against Influenza A virus in Raw 264.7 Cells

Influenza A virus (IAV) remains a major public health concern due to its high infectivity, potential for rapid mutation, and significant morbidity and mortality rates. Developing alternative and natural therapeutic agents has become critical in combating this virus, especially given rising antiviral resistance. Honey, particularly from Korean Native bees, is known for its medicinal properties, including its antioxidant, anti-inflammatory, and immune-modulatory effects. This study investigates the protective effects of Korean Native bee-honey on IAV-infected Raw 264.7 murine macrophage cells, focusing on viral replication, and modulation of immune responses.<br/>Our findings indicate that treatment with Korean Native bee-honey enhances the survival of infected Raw 264.7 cells, reduces viral replication, and promotes immune responses via upregulation of innate immune cytokines. These results suggest that Korean Native bee-honey could be a valuable natural intervention for managing influenza infections, warranting further exploration for its therapeutic potential in antiviral defense.