MITOCHONDRIAL DYSFUNCTION IN THE GENESIS OF PLACENTAL PATHOLOGY: PERINATAL OUTCOMES

The human placenta is a unique organ with a temporary functioning period of about 280 days on average. All changes associated with the physiology of mitochondria, the aging process of the placenta, adaptation to changing conditions or dysfunction of the placenta directly affect the performance of the placenta's functions, as well as the development of the fetus. Modern studies studying the causes of intrauterine growth disorders of the fetus demonstrate the implementation of a chain of mechanisms of placental dysfunction, which leads to a slowdown in fetal growth with a subsequent slowdown in physical development at an early age. The literature review presents modern research in the field of studying the adaptive mechanisms of mitochondria during various periods of gestation and their relationship with neonatal pathology