Association of ABO Gene rs2073823 Polymorphism with Microvascular Complications, sP-Selectin Levels and Lipid Profile in Type 2 Diabetes
The ABO rs2073823 polymorphism, particularly the "A/A" genotype, is associated with a decreased risk of MVCs in T2D patients and influences lipid metabolism and inflammatory markers. These findings suggest a genetic basis for the susceptibility to MVCs and highlight the role of the ABO gene in modulating inflammation and endothelial function in T2D. Further research is needed to validate these associations and explore potential therapeutic implications.
Authors
- H. Abdesselem (ORCID: https://orcid.org/0000-0001-6886-6036)
- Mohamed Kacem Ben Fradj (ORCID: https://orcid.org/0000-0001-5992-8856)
- Rym Ben Othman (ORCID: https://orcid.org/0000-0002-2453-9778)
- Zahraa Saad Hatef
- Haithem Rauf Mohammed (ORCID: https://orcid.org/0000-0001-6456-9907)
Institutions
- Tunis University (TN)
- University of Monastir (TN)
- Hôpital La Rabta (TN)
- Institut National de Nutrition et de Technologie Alimentaire (TN)
- University of Kerbala (IQ)
- Faculté de médecine de Tunis
- Tunis El Manar University (TN)
Publication Details
- Journal
- Current Diabetes Reviews
- Published
- 2025-08-25
- DOI
- https://doi.org/10.2174/0115733998341750241208055924
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00