CLINICAL EVALUATION OF MUTRASAMGRAHANIYA KARMA (ANTIDIURETIC) OF AMRASTHI MAJJA CHURNA (KERNEL POWDER OF MANGIFERAINDICA LINN.) IN THE MANAGEMENT OF PRABHUT-MUTRATA (POLYURIA)AS PER SAMANYA-VISHESHA SIDDHANTA.

Background: Acharya Charaka classified medicinal plants based on their pharmaco-therapeutic properties, providing a valuable reference for Ayurvedic practitioners. In the Shadvirechanashatashritiya chapter, he de-scribed the Mutrasangrahaniya (anti-diuretic) Mahakashaya. According to Ayurvedic texts, Prabhuta Mutrata (polyuria) is characterised by increased frequency and volume of urination. This condition is commonly ob-served in disorders such as Prameha (diabetes and metabolic disorders), Arsha (haemorrhoids), Jwara (fever), and several other pathological states. Polyuria often causes significant social discomfort and embarrassment for affected individuals. In this context, Amra (Mangifera indica Linn.), a plant included in the Mutrasangrahaniya Mahakashaya, was selected for a clinical trial to evaluate its efficacy in managing Prabhuta Mutrata. Methods: The study included 40 randomly selected subjects based on predefined inclusion and exclusion criteria. Amrasthi Majja Churna (3 g) was administered orally twice daily before meals for 30 days. The primary symptom, urinary frequency during day and night, was assessed using a gradation scale. The non-parametric data obtained from the study were analysed using the Wilcoxon Signed-Rank Test. Conclusion: This study provided evidence to revalidate the concept of Mutrasangrahaniya Karma (anti-diuretic action) of Amrasthi Majja Churna in the management of Prabhuta Mutrata (polyuria), in alignment with the Samanya-Vishesha Siddhanta (the principle of similarity and dissimilarity) described in Ayurveda.