LEIGH SYNDROME IS SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY (A CLINICAL CASE)

Leigh syndrome is a systemic mitochondrial disease caused by mutations in the genes responsible for the synthesis of polypeptides that are part of the complexes of the mitochondrial respiratory chain, as well as proteins involved in the process of their assembly. 262 The clinical differential diagnosis of mitochondrial diseases is one of the most difficult in pediatric neurology. This article examines a case of clinical observation of a child diagnosed with subacute necrotizing encephalomyelopathy. The clinical symptoms of the disease are described, as well as the results of laboratory and instrumental studies that were conducted to clarify the diagnosis.